The plant trans-Golgi network acts as a hub for both secretory and endocytic trafficking ad delicate mechanisms are in place to balance trafficking in and out of this organelle, including pH and ion gradients. This collaboration, led by Stefanie Wege’s group at the University of Adelaide, provided compelling evidence that the single isoform of cation chloride cotransporter (CCC1) encoded in Arabidopsis thaliana provides a cation and anion efflux mechanism to regulate pH in the trans-Golgi network/early endosome and has now been published in eLife.